Can selection occur without natural selection? Background Genetic Drift is a change in allele frequency in a population due to random selection of genes. Mutations in the DNA can have no effect on the fitness of an organism. This means that even if evolution has occurred natural selection would not. These genetic changes can increase or decrease among the population. When an allele does not change the frequency in a population then genetic drift is acting on the allele. Allele frequencies tend to stay relatively stable in large populations because the gene does not affect fitness. However, in small populations fluctuation can occur leading to evolution - some alleles will become fixed and while others will disappear. Genetic Drift in COVID-19 The genome of coronavirus is prone to mutations that can lead to genetic drift. It is crucial for vaccine developers to consider the sub-strains mutations. By using epitope information in spike protein (S), nucleocapsid protein (N), and...